diff --git a/src/chacha20poly1305.c b/src/chacha20poly1305.c
index 86157dc0..a48bcdc4 100644
--- a/src/chacha20poly1305.c
+++ b/src/chacha20poly1305.c
@@ -10,6 +10,14 @@
 #include "mystdint.h"
 #include <string.h>
 
+#if defined(__wasm_simd128__)
+#include <wasm_simd128.h>
+#elif defined(__SSE4_1__)
+#include <immintrin.h>
+#elif defined(__aarch64__)
+#include <arm_neon.h>
+#endif
+
 #define ROL32(x, c) (((x) << (c)) | ((x) >> (32-(c))))
 #define ROR32(x, c) (((x) >> (c)) | ((x) << (32-(c))))
 
@@ -215,6 +223,21 @@ void poly1305(const uint8_t* msg, size_t n, const uint8_t key[32],
 SQLITE_PRIVATE
 int poly1305_tagcmp(const uint8_t tag1[16], const uint8_t tag2[16])
 {
+#if defined(__wasm_simd128__)
+  v128_t tagDifference = wasm_v128_xor(
+    wasm_v128_load(tag1), wasm_v128_load(tag2));
+  return wasm_v128_any_true(tagDifference);
+#elif defined(__SSE4_1__)
+  __m128i tag1_vec = _mm_loadu_si128((const __m128i*)tag1);
+  __m128i tag2_vec = _mm_loadu_si128((const __m128i*)tag2);
+  __m128i tagDifference = _mm_xor_si128(tag1_vec, tag2_vec);
+  return !_mm_testz_si128(tagDifference, tagDifference);
+#elif defined(__aarch64__)
+  uint8x16_t tag1_vec = vld1q_u8(tag1);
+  uint8x16_t tag2_vec = vld1q_u8(tag2);
+  uint8x16_t tagDifference = veorq_u8(tag1_vec, tag2_vec);
+  return vmaxvq_u8(tagDifference) != 0;
+#else
   uint8_t d = 0;
   d |= tag1[ 0] ^ tag2[ 0];
   d |= tag1[ 1] ^ tag2[ 1];
@@ -233,6 +256,7 @@ int poly1305_tagcmp(const uint8_t tag1[16], const uint8_t tag2[16])
   d |= tag1[14] ^ tag2[14];
   d |= tag1[15] ^ tag2[15];
   return (int) d;
+#endif
 }
 
 /*