diff --git a/mypyc/irbuild/expression.py b/mypyc/irbuild/expression.py
index 5e319449290c..d6d672c859b0 100644
--- a/mypyc/irbuild/expression.py
+++ b/mypyc/irbuild/expression.py
@@ -111,7 +111,7 @@
     vec_api_by_item_type,
 )
 from mypyc.irbuild.ast_helpers import is_borrow_friendly_expr, process_conditional
-from mypyc.irbuild.builder import IRBuilder, int_borrow_friendly_op
+from mypyc.irbuild.builder import IRBuilder, expr_has_suspend, int_borrow_friendly_op
 from mypyc.irbuild.constant_fold import constant_fold_expr
 from mypyc.irbuild.for_helpers import (
     comprehension_helper,
@@ -1613,10 +1613,25 @@ def transform_generator_expr(builder: IRBuilder, o: GeneratorExpr) -> Value:
     if isinstance(o.left_expr, StarExpr):
         builder.error("Unpacking in comprehensions is not supported yet", o.line)
         return builder.none()
+    if is_async_generator_expr(o):
+        builder.error("Async generator expressions are not supported", o.line)
+        return builder.none()
     builder.warning("Treating generator comprehension as list", o.line)
     return builder.primitive_op(iter_op, [translate_generator_to_list(builder, o)], o.line)
 
 
+def is_async_generator_expr(o: GeneratorExpr) -> bool:
+    """Is this an async generator expression (it has 'async for' or 'await')?
+
+    The first iterable is evaluated in the enclosing scope, so an 'await' there doesn't
+    make the generator expression async.
+    """
+    if any(o.is_async):
+        return True
+    parts = [o.left_expr, *o.sequences[1:]] + [cond for conds in o.condlists for cond in conds]
+    return any(expr_has_suspend(e) for e in parts)
+
+
 def transform_assignment_expr(builder: IRBuilder, o: AssignmentExpr) -> Value:
     value = builder.accept(o.value)
     target = builder.get_assignment_target(o.target)
diff --git a/mypyc/test-data/irbuild-basic.test b/mypyc/test-data/irbuild-basic.test
index 83b2a16be791..af1859e3a110 100644
--- a/mypyc/test-data/irbuild-basic.test
+++ b/mypyc/test-data/irbuild-basic.test
@@ -3868,3 +3868,17 @@ def get_length():
 L0:
     r0 = 'https://w3id.org/cwl/salad#'
     return 54
+
+[case testAsyncGeneratorExprNotSupported]
+from typing import AsyncIterator
+
+async def h(x: int) -> int:
+    return x
+
+async def f(xs: list[int], a: AsyncIterator[int]) -> None:
+    g1 = (await h(x) for x in xs)  # E: Async generator expressions are not supported
+    g2 = (x async for x in a)  # E: Async generator expressions are not supported
+    g3 = (x for x in xs if [y async for y in a])  # E: Async generator expressions are not supported
+    # An 'await' in the first iterable is evaluated in the enclosing function.
+    g4 = (x for x in [await h(1)])  # W: Treating generator comprehension as list
+[typing fixtures/typing-full.pyi]