diff --git a/tsc/internal/bundled/libs/lib.dom.d.ts b/tsc/internal/bundled/libs/lib.dom.d.ts
index 9e127c3f5a524..55b1eb056bf74 100644
--- a/tsc/internal/bundled/libs/lib.dom.d.ts
+++ b/tsc/internal/bundled/libs/lib.dom.d.ts
@@ -11170,7 +11170,7 @@ interface Crypto {
      *
      * [MDN Reference](https://developer.mozilla.org/docs/Web/API/Crypto/getRandomValues)
      */
-    getRandomValues<T extends Exclude<BufferSource, ArrayBuffer>>(array: T): T;
+    getRandomValues<T extends IntegerTypedArray>(array: T): T;
     /**
      * The **`randomUUID()`** method of the Crypto interface is used to generate a v4 UUID using a cryptographically secure random number generator.
      * Available only in secure contexts.
diff --git a/tsc/internal/bundled/libs/lib.es2020.bigint.d.ts b/tsc/internal/bundled/libs/lib.es2020.bigint.d.ts
index fde848f721684..8000584f799e0 100644
--- a/tsc/internal/bundled/libs/lib.es2020.bigint.d.ts
+++ b/tsc/internal/bundled/libs/lib.es2020.bigint.d.ts
@@ -722,6 +722,11 @@ interface BigUint64ArrayConstructor {
 }
 declare var BigUint64Array: BigUint64ArrayConstructor;
 
+interface IntegerTypedArrayTypes {
+    BigInt64Array: BigInt64Array<ArrayBufferLike>;
+    BigUint64Array: BigUint64Array<ArrayBufferLike>;
+}
+
 interface DataView<TArrayBuffer extends ArrayBufferLike> {
     /**
      * Gets the BigInt64 value at the specified byte offset from the start of the view. There is
diff --git a/tsc/internal/bundled/libs/lib.es5.d.ts b/tsc/internal/bundled/libs/lib.es5.d.ts
index e394111cb0e6c..5544db0e0b4d2 100644
--- a/tsc/internal/bundled/libs/lib.es5.d.ts
+++ b/tsc/internal/bundled/libs/lib.es5.d.ts
@@ -4409,6 +4409,21 @@ interface Float64ArrayConstructor {
 }
 declare var Float64Array: Float64ArrayConstructor;
 
+/**
+ * Stores the typed array types that hold integers, such as those accepted by `crypto.getRandomValues`.
+ */
+interface IntegerTypedArrayTypes {
+    Int8Array: Int8Array<ArrayBufferLike>;
+    Int16Array: Int16Array<ArrayBufferLike>;
+    Int32Array: Int32Array<ArrayBufferLike>;
+    Uint8Array: Uint8Array<ArrayBufferLike>;
+    Uint16Array: Uint16Array<ArrayBufferLike>;
+    Uint32Array: Uint32Array<ArrayBufferLike>;
+    Uint8ClampedArray: Uint8ClampedArray<ArrayBufferLike>;
+}
+
+type IntegerTypedArray = IntegerTypedArrayTypes[keyof IntegerTypedArrayTypes];
+
 /////////////////////////////
 /// ECMAScript Internationalization API
 /////////////////////////////
diff --git a/tsc/internal/bundled/libs/lib.webworker.d.ts b/tsc/internal/bundled/libs/lib.webworker.d.ts
index 45c6a6134821d..1534323fa4784 100644
--- a/tsc/internal/bundled/libs/lib.webworker.d.ts
+++ b/tsc/internal/bundled/libs/lib.webworker.d.ts
@@ -3183,7 +3183,7 @@ interface Crypto {
      *
      * [MDN Reference](https://developer.mozilla.org/docs/Web/API/Crypto/getRandomValues)
      */
-    getRandomValues<T extends Exclude<BufferSource, ArrayBuffer>>(array: T): T;
+    getRandomValues<T extends IntegerTypedArray>(array: T): T;
     /**
      * The **`randomUUID()`** method of the Crypto interface is used to generate a v4 UUID using a cryptographically secure random number generator.
      * Available only in secure contexts.
diff --git a/tsc/internal/fourslash/tests/util/util.go b/tsc/internal/fourslash/tests/util/util.go
index 6c2285301d78c..b44b9174b0716 100644
--- a/tsc/internal/fourslash/tests/util/util.go
+++ b/tsc/internal/fourslash/tests/util/util.go
@@ -1162,6 +1162,16 @@ var CompletionGlobalTypeDecls = []fourslash.CompletionsExpectedItem{
 		Kind:     new(lsproto.CompletionItemKindInterface),
 		SortText: new(string(ls.SortTextGlobalsOrKeywords)),
 	},
+	&lsproto.CompletionItem{
+		Label:    "IntegerTypedArray",
+		Kind:     new(lsproto.CompletionItemKindClass),
+		SortText: new(string(ls.SortTextGlobalsOrKeywords)),
+	},
+	&lsproto.CompletionItem{
+		Label:    "IntegerTypedArrayTypes",
+		Kind:     new(lsproto.CompletionItemKindInterface),
+		SortText: new(string(ls.SortTextGlobalsOrKeywords)),
+	},
 	&lsproto.CompletionItem{
 		Label:    "Intl",
 		Kind:     new(lsproto.CompletionItemKindModule),
diff --git a/tsc/testdata/baselines/reference/compiler/integerTypedArray.errors.txt b/tsc/testdata/baselines/reference/compiler/integerTypedArray.errors.txt
new file mode 100644
index 0000000000000..3604a28fcc75e
--- /dev/null
+++ b/tsc/testdata/baselines/reference/compiler/integerTypedArray.errors.txt
@@ -0,0 +1,30 @@
+integerTypedArray.ts(3,24): error TS2345: Argument of type 'Float64Array<ArrayBuffer>' is not assignable to parameter of type 'IntegerTypedArray'.
+  Type 'Float64Array<ArrayBuffer>' is not assignable to type 'Uint8ClampedArray<ArrayBufferLike>'.
+    The types returned by 'filter(...)[Symbol.toStringTag]' are incompatible between these types.
+      Type '"Float64Array"' is not assignable to type '"Uint8ClampedArray"'.
+integerTypedArray.ts(4,24): error TS2345: Argument of type 'null' is not assignable to parameter of type 'IntegerTypedArray'.
+
+
+==== integerTypedArray.ts (2 errors) ====
+    crypto.getRandomValues(new Uint8Array(1));
+    crypto.getRandomValues(new BigInt64Array(1));
+    crypto.getRandomValues(new Float64Array(1));
+                           ~~~~~~~~~~~~~~~~~~~
+!!! error TS2345: Argument of type 'Float64Array<ArrayBuffer>' is not assignable to parameter of type 'IntegerTypedArray'.
+!!! error TS2345:   Type 'Float64Array<ArrayBuffer>' is not assignable to type 'Uint8ClampedArray<ArrayBufferLike>'.
+!!! error TS2345:     The types returned by 'filter(...)[Symbol.toStringTag]' are incompatible between these types.
+!!! error TS2345:       Type '"Float64Array"' is not assignable to type '"Uint8ClampedArray"'.
+    crypto.getRandomValues(null);
+                           ~~~~
+!!! error TS2345: Argument of type 'null' is not assignable to parameter of type 'IntegerTypedArray'.
+    
+    declare const buffer: Uint8Array<ArrayBufferLike>;
+    crypto.getRandomValues(buffer);
+    
+    declare const array: Parameters<typeof crypto.getRandomValues>[0];
+    const values = crypto.getRandomValues(array);
+    values.BYTES_PER_ELEMENT;
+    
+    declare const integers: IntegerTypedArray;
+    const ints: IntegerTypedArrayTypes["Int32Array"] = new Int32Array(1);
+    
\ No newline at end of file
diff --git a/tsc/testdata/baselines/reference/compiler/integerTypedArray.js b/tsc/testdata/baselines/reference/compiler/integerTypedArray.js
new file mode 100644
index 0000000000000..f183d258c3db4
--- /dev/null
+++ b/tsc/testdata/baselines/reference/compiler/integerTypedArray.js
@@ -0,0 +1,29 @@
+//// [tests/cases/compiler/integerTypedArray.ts] ////
+
+//// [integerTypedArray.ts]
+crypto.getRandomValues(new Uint8Array(1));
+crypto.getRandomValues(new BigInt64Array(1));
+crypto.getRandomValues(new Float64Array(1));
+crypto.getRandomValues(null);
+
+declare const buffer: Uint8Array<ArrayBufferLike>;
+crypto.getRandomValues(buffer);
+
+declare const array: Parameters<typeof crypto.getRandomValues>[0];
+const values = crypto.getRandomValues(array);
+values.BYTES_PER_ELEMENT;
+
+declare const integers: IntegerTypedArray;
+const ints: IntegerTypedArrayTypes["Int32Array"] = new Int32Array(1);
+
+
+//// [integerTypedArray.js]
+"use strict";
+crypto.getRandomValues(new Uint8Array(1));
+crypto.getRandomValues(new BigInt64Array(1));
+crypto.getRandomValues(new Float64Array(1));
+crypto.getRandomValues(null);
+crypto.getRandomValues(buffer);
+const values = crypto.getRandomValues(array);
+values.BYTES_PER_ELEMENT;
+const ints = new Int32Array(1);
diff --git a/tsc/testdata/baselines/reference/compiler/integerTypedArray.symbols b/tsc/testdata/baselines/reference/compiler/integerTypedArray.symbols
new file mode 100644
index 0000000000000..adcb98dddd4b2
--- /dev/null
+++ b/tsc/testdata/baselines/reference/compiler/integerTypedArray.symbols
@@ -0,0 +1,65 @@
+//// [tests/cases/compiler/integerTypedArray.ts] ////
+
+=== integerTypedArray.ts ===
+crypto.getRandomValues(new Uint8Array(1));
+>crypto.getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>crypto : Symbol(crypto, Decl(lib.dom.d.ts, --, --))
+>getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>Uint8Array : Symbol(Uint8Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --) ... and 4 more)
+
+crypto.getRandomValues(new BigInt64Array(1));
+>crypto.getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>crypto : Symbol(crypto, Decl(lib.dom.d.ts, --, --))
+>getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>BigInt64Array : Symbol(BigInt64Array, Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2022.array.d.ts, --, --), Decl(lib.es2023.array.d.ts, --, --))
+
+crypto.getRandomValues(new Float64Array(1));
+>crypto.getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>crypto : Symbol(crypto, Decl(lib.dom.d.ts, --, --))
+>getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>Float64Array : Symbol(Float64Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --) ... and 3 more)
+
+crypto.getRandomValues(null);
+>crypto.getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>crypto : Symbol(crypto, Decl(lib.dom.d.ts, --, --))
+>getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+
+declare const buffer: Uint8Array<ArrayBufferLike>;
+>buffer : Symbol(buffer, Decl(integerTypedArray.ts, 5, 13))
+>Uint8Array : Symbol(Uint8Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --) ... and 4 more)
+>ArrayBufferLike : Symbol(ArrayBufferLike, Decl(lib.es5.d.ts, --, --))
+
+crypto.getRandomValues(buffer);
+>crypto.getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>crypto : Symbol(crypto, Decl(lib.dom.d.ts, --, --))
+>getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>buffer : Symbol(buffer, Decl(integerTypedArray.ts, 5, 13))
+
+declare const array: Parameters<typeof crypto.getRandomValues>[0];
+>array : Symbol(array, Decl(integerTypedArray.ts, 8, 13))
+>Parameters : Symbol(Parameters, Decl(lib.es5.d.ts, --, --))
+>crypto.getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>crypto : Symbol(crypto, Decl(lib.dom.d.ts, --, --))
+>getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+
+const values = crypto.getRandomValues(array);
+>values : Symbol(values, Decl(integerTypedArray.ts, 9, 5))
+>crypto.getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>crypto : Symbol(crypto, Decl(lib.dom.d.ts, --, --))
+>getRandomValues : Symbol(Crypto.getRandomValues, Decl(lib.dom.d.ts, --, --))
+>array : Symbol(array, Decl(integerTypedArray.ts, 8, 13))
+
+values.BYTES_PER_ELEMENT;
+>values.BYTES_PER_ELEMENT : Symbol(BYTES_PER_ELEMENT, Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --) ... and 4 more)
+>values : Symbol(values, Decl(integerTypedArray.ts, 9, 5))
+>BYTES_PER_ELEMENT : Symbol(BYTES_PER_ELEMENT, Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --) ... and 4 more)
+
+declare const integers: IntegerTypedArray;
+>integers : Symbol(integers, Decl(integerTypedArray.ts, 12, 13))
+>IntegerTypedArray : Symbol(IntegerTypedArray, Decl(lib.es5.d.ts, --, --))
+
+const ints: IntegerTypedArrayTypes["Int32Array"] = new Int32Array(1);
+>ints : Symbol(ints, Decl(integerTypedArray.ts, 13, 5))
+>IntegerTypedArrayTypes : Symbol(IntegerTypedArrayTypes, Decl(lib.es5.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --))
+>Int32Array : Symbol(Int32Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --) ... and 3 more)
+
diff --git a/tsc/testdata/baselines/reference/compiler/integerTypedArray.types b/tsc/testdata/baselines/reference/compiler/integerTypedArray.types
new file mode 100644
index 0000000000000..25a43575154c0
--- /dev/null
+++ b/tsc/testdata/baselines/reference/compiler/integerTypedArray.types
@@ -0,0 +1,74 @@
+//// [tests/cases/compiler/integerTypedArray.ts] ////
+
+=== integerTypedArray.ts ===
+crypto.getRandomValues(new Uint8Array(1));
+>crypto.getRandomValues(new Uint8Array(1)) : Uint8Array<ArrayBuffer>
+>crypto.getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>crypto : Crypto
+>getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>new Uint8Array(1) : Uint8Array<ArrayBuffer>
+>Uint8Array : Uint8ArrayConstructor
+>1 : 1
+
+crypto.getRandomValues(new BigInt64Array(1));
+>crypto.getRandomValues(new BigInt64Array(1)) : BigInt64Array<ArrayBuffer>
+>crypto.getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>crypto : Crypto
+>getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>new BigInt64Array(1) : BigInt64Array<ArrayBuffer>
+>BigInt64Array : BigInt64ArrayConstructor
+>1 : 1
+
+crypto.getRandomValues(new Float64Array(1));
+>crypto.getRandomValues(new Float64Array(1)) : IntegerTypedArray
+>crypto.getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>crypto : Crypto
+>getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>new Float64Array(1) : Float64Array<ArrayBuffer>
+>Float64Array : Float64ArrayConstructor
+>1 : 1
+
+crypto.getRandomValues(null);
+>crypto.getRandomValues(null) : IntegerTypedArray
+>crypto.getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>crypto : Crypto
+>getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+
+declare const buffer: Uint8Array<ArrayBufferLike>;
+>buffer : Uint8Array<ArrayBufferLike>
+
+crypto.getRandomValues(buffer);
+>crypto.getRandomValues(buffer) : Uint8Array<ArrayBufferLike>
+>crypto.getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>crypto : Crypto
+>getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>buffer : Uint8Array<ArrayBufferLike>
+
+declare const array: Parameters<typeof crypto.getRandomValues>[0];
+>array : IntegerTypedArray
+>crypto.getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>crypto : Crypto
+>getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+
+const values = crypto.getRandomValues(array);
+>values : IntegerTypedArray
+>crypto.getRandomValues(array) : IntegerTypedArray
+>crypto.getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>crypto : Crypto
+>getRandomValues : <T extends IntegerTypedArray>(array: T) => T
+>array : IntegerTypedArray
+
+values.BYTES_PER_ELEMENT;
+>values.BYTES_PER_ELEMENT : number
+>values : IntegerTypedArray
+>BYTES_PER_ELEMENT : number
+
+declare const integers: IntegerTypedArray;
+>integers : IntegerTypedArray
+
+const ints: IntegerTypedArrayTypes["Int32Array"] = new Int32Array(1);
+>ints : Int32Array<ArrayBufferLike>
+>new Int32Array(1) : Int32Array<ArrayBuffer>
+>Int32Array : Int32ArrayConstructor
+>1 : 1
+
diff --git a/tsc/testdata/tests/cases/compiler/integerTypedArray.ts b/tsc/testdata/tests/cases/compiler/integerTypedArray.ts
new file mode 100644
index 0000000000000..01c0f15a14b7f
--- /dev/null
+++ b/tsc/testdata/tests/cases/compiler/integerTypedArray.ts
@@ -0,0 +1,18 @@
+// @strict: true
+// @target: esnext
+// @lib: esnext,dom
+
+crypto.getRandomValues(new Uint8Array(1));
+crypto.getRandomValues(new BigInt64Array(1));
+crypto.getRandomValues(new Float64Array(1));
+crypto.getRandomValues(null);
+
+declare const buffer: Uint8Array<ArrayBufferLike>;
+crypto.getRandomValues(buffer);
+
+declare const array: Parameters<typeof crypto.getRandomValues>[0];
+const values = crypto.getRandomValues(array);
+values.BYTES_PER_ELEMENT;
+
+declare const integers: IntegerTypedArray;
+const ints: IntegerTypedArrayTypes["Int32Array"] = new Int32Array(1);